Evolution of psoriasis treatments – what do the new treatment options mean for patients

In the past few years we have learned more about the pathophysiology, and the immunological mechanisms of psoriasis. This knowledge has further been translated into novel biologic treatments that have new mechanisms of action. The most recent innovations are the interleukin-23 inhibitors.1 As a result of this progress in science and technology, dermatologists now have more treatment options for patients with psoriasis compared to the past.

Dr. Kim Papp from Canada, who is a one of the top dermatologists in the world specializing in psoriasis,  has contributed to clinical development of most biologic psoriasis treatments (read more here). Janssen recently interviewed Dr. Kim Papp and asked what the new treatment options mean for dermatologists and especially for patients.

 

How to choose a biologic treatment?
 

Psoriasis is a complex disease with skin symptoms that are often accompanied with various co-morbidities.2 What are the patient characteristics and factors that Dr. Kim Papp considers when choosing the optimal treatment choice for his patients?

Why aim for clear skin? Efficacy from the patient perspective

New biologic treatments have increased the expectations on treatment efficacy.  Research also shows that high treatment response on skin correlates with improvements in quality of life. 3 But what does this mean in clinical practice, and what are Dr. Kim Papp’s treatment goals for psoriasis patients?

 

Interested to learn more? Below you find links to articles addressing the topics discussed by Dr. Kim Papp. 

 

References

  1. Shifting the focus - the primary role of IL-23 in psoriasis and other inflammatory disorders Gooderham MJ, Papp KA, Lynde CW. J Eur Acad Dermatol Venereol. 2018 Jul;32(7):1111-1119. doi: 10.1111/jdv.14868. Epub 2018 Mar 9. https://www.ncbi.nlm.nih.gov/pubmed/29438576. This article gives an overview of the immunopathology of psoriasis, and describes how this has led to development of novel and more specific biologic treatments for psoriasis patients
  2. Psoriasis and comorbid diseases: Implications for management. Takeshita J, Grewal S, Langan SM, et al.  J Am Acad Dermatol. 2017 Mar;76(3):393-403. doi: 10.1016/j.jaad.2016.07.065. https://www.ncbi.nlm.nih.gov/pubmed/28212760. This article provides a good overview to the available epidemiological data about co-morbidities of psoriasis. 
  3. Improvement in Patient-Reported Outcomes (Dermatology Life Quality Index and the Psoriasis Symptoms and Signs Diary) with Guselkumab in Moderate-to-Severe Plaque Psoriasis: Results from the Phase III VOYAGE 1 and VOYAGE 2 Studies. Armstrong AW, Reich K, Foley P, et al. Am J Clin Dermatol. 2019 Feb;20(1):155-164. doi: 10.1007/s40257-018-0396-z. https://www.ncbi.nlm.nih.gov/pubmed/30417277. This article is an quality of life analysis of guselkumab VOYAGE 1 and VOYAGE 2 studies. These results clearly show that clear skin correlates to achievement of DLQI score 0/1.